Levofloxacin-loaded polymeric nanoparticles can produce a biphasic extended release which can reduce the dosing frequency
Investigators in the School of Chemical and Biomedical Engineering, Nanyang Technology University, Singapore, have examined the antibiotic release profiles of levofloxacin-loaded polymeric nanoparticles and their effect on E. coli biofilm cells.
They found that the production of a biphasic extended release profile using a suitable dose of levofloxacin inhibited biofilm growth for four days which allowed the dosing frequency to be reduced. The release profile is just as important as the levofloxacin dose as far as the biofilm eradication rate is concerned.
Phar. Res. 2010 Apr 21. [Epub ahead of print]
Source : http://www.ncbi.nlm.nih.gov/pubmed/20407918?dopt=Abstract