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A rat model of foreign body infection suggests that levoflocacin alone is more effective than a combination with rifampin Researchers in the Laboratory of Experimental Infection, University Hospital of Bellvitge, Barcelona, Spain, have used a staphylococcal rat model of foreign body infection to examine the efficacy of levofloxacin alone compared with a levofloxacin-rifampin combination. They found that the most effective treatment was high-dose levofloxacin (100 mg/kg/day) alone given for a period of 7 days and this was not associated with the emergence of resistant strains. Rifampin actually had an antagonistic effect on the action of levofloxacin. PMID: 18676888 Antimicrob Agents Chemother. 2008 Aug 1; [Epub ahead of print] |
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