Quinolones News

#2 December 4, 2006

Japanese scientists find point mutations responsible for fluoroquinolone resistance in H. pylori infections

Researchers in the Department of Internal Medicine, Keio University, Tokyo, and the Department of Gastroenterology, Eiju Hospital, Japan, have examined clinical Helicobacter pylori isolates from 51 patients with H. pylori infections who did not respond to drug treatment.

They developed a rapid test using an allele-specific polymerase chain reaction and were able to identify gyrA mutations of H. pylori with reduced susceptibility to gatifloxacin.

They believe that their method will be useful for the rapid and simple identification of fluoroquinolone-resistant strains of H. pylori.

PMID: 17122023

J. Clin. Microbiol. 2006 Nov 22; [Epub ahead of print]

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Last updated December 4, 2006